Process optimization of physicochemical properties of spray-dried Hydrocotyle umbellata L. extract

Abstract Hydrocotyle umbellata L., Araliaceae, is a species that is recommended in Ayurvedic medicine for its effects on the central nervous system, such as anxiolytic and memory-stimulant effects. Despite the medicinal potential of this species, its phytopharmaceutical and technological potential to produce standardized extracts has not been investigated. This study analyzes the influence of spray drying parameters on the contents of the chemical markers (total phenolic, total flavonoid, and hibalactone) and the functional properties of H. umbellata extract. The optimization of drying conditions was performed using a central composite design combined with response surface methodology and desirability function approach. The mathematical models fitted to experimental data indicated that all the evaluated drying parameters significantly influenced the chemical contents. The optimal conditions were: inlet temperature of 120 °C, feed flow rate of 4 mL min-1, and colloidal silicon dioxide:maltodextrin ratio of 16%:4%. Under these conditions, the powder samples had spherical particles and desirable physicochemical and functional properties, such as low water activity and moisture content, good product recovery, reconstitution, and flowability. Thus, spray drying might be a promising technique for processing standardized H. umbellata extracts.

Gastroprotective potential and mechanisms of action of Hedera nepalensis

Abstract Hedera nepalensis (H. nepalensis) , belonging to the family Araliaceae, is a medicinal plant traditionally used to treat stomach problems. The current study investigated the gastroprotective potential and the mechanism of action of H. nepalensis in diclofenac-and ethanol-induced ulcer models. Anti-oxidant and lipid peroxidation inhibitory prospects of H. nepalensis were checked out by free radical scavenging assay and UV spectrophotometer respectively. Effect of H. nepalensis on the pH, gastric total acidity of gastric juice and protective effects of H. nepalensis against ulcer models have been examined. Histopathological studies have been carried out. The aqueous methanol extract of H. nepalensis (100 µg/mL) showed anti-oxidant (83.55%) and lipid peroxidation inhibitory (70.88%) potential at 1000 µg/mL; the extract had no buffer potential. The extract (400 mg/kg) significantly (81.12% and 63.46%) showed gastroprotective effect in diclofenac and ethanol-induced rat ulcer models respectively. Histopathological studies confirmed the biochemical findings. FTIR analysis showed the presence of carboxylic acid, alkanes, conjugated alkanes, aldehydes and alkyl-aryl ethers. Gallic acid, M-coumaric acid and quercetin were found by HPLC analysis. H. nepalensis exhibited significant protection against diclofenac and ethanol induced gastric damage by anti-oxidant and lipid peroxidation suppression effects suggesting potential broad utility in treatment of diseases characterized with gastric damage.

Ethnopharmacological activity of Hedera nepalensis K. Koch extracts and lupeol against alloxan-induced type I diabetes

In this study, we investigated the protective effects of Hedera nepalensis crude extract, its fractions and lupeol in alloxan-induced diabetic rats. Lupeol and n-hexane (HNN) fraction significantly reduced the blood glucose level by increasing insulin level in time dependent manner, and also significantly increased amylase and lipase activity in diabetic rats. Elevated levels of alanine transaminases (ALT), aspartate transaminases (AST), thiobarbituric acid reactive substances (TBARS), nitrite, hydrogen peroxide (H2O2), total bilirubin and total protein in blood serum were efficiently restored to normal levels. Suppressed enzymatic activity of catalase (CAT), superoxide dismutase (SOD), reduced glutathione (GSH) and peroxidase (POD) were also restored to their normal levels. Kidney functions were also restored to normal level after treatment with HNN and lupeol. HNN fraction and lupeol of H. nepalensis prevented oxidative stress in alloxan-induced diabetic rats. This study signifies the importance of H. nepalensis and lupeol in ameliorating diabetes by inducing insulin secretion in diabetic model rats.

New records of medicinal plants in Tibet / 中国中药杂志

By the fourth survey of Chinese medicinal resources, new medicinal plants records of 2 genera and 5 species were reported in Tibet. They are two genera Rhynchoglossum and Asteropyrum, and five species including Rh. obliquum, A. peltatum, Urena repanda, Schefflera khasiana and Mimulus tenellus. All the voucher specimens are preserved in Herbarium of Tibet Agriculture and Animal Husbandry University.

Effects of an accidental dry-season fire on the reproductive phenology of two Neotropical savanna shrubs / Efeitos de um incêndio acidental de estação seca sobre a fenologia reprodutiva de dois arbustos savânicos neotropicais

Abstract Fire is a recurrent disturbance in savanna vegetation and savanna species are adapted to it. Even so, fire may affect various aspects of plant ecology, including phenology. We studied the effects of a spatially heterogeneous fire on the reproductive phenology of two dominant woody plant species, Miconia albicans (Melastomataceae) and Schefflera vinosa (Araliaceae), in a savanna area in South-eastern Brazil. The study site was partially burnt by a dry-season accidental fire in August 2006, and we monitored the phenolology of 30 burnt and 30 unburnt individuals of each species between September 2007 and September 2008. We used restricted randomizations to assess phenological differences between the burnt and unburnt individuals. Fire had negative effects on the phenology of M. albicans, with a smaller production of reproductive structures in general and of floral buds, total fruits, and ripe fruits in burnt plants. All unburnt but only 16% of the burnt M. albicans plants produced ripe fruits during the study. Fire effects on S. vinosa were smaller, but there was a greater production of floral buds and fruits (but not ripe fruits) by burnt plants; approximately 90% of the individuals of S. vinosa produced ripe fruits during the study, regardless of having been burnt or not. The differences between the two species may be related to S. vinosa's faster growth and absence from the seed bank at the study site, whereas M. albicans grows more slowly and is dominant in the seed bank.

Resumo O fogo é uma perturbação recorrente em vegetação savânica e as espécies do cerrado são adaptadas a ele. Mesmo assim, o fogo pode afetar aspectos da ecologia vegetal, incluindo a fenologia. Nós estudamos os efeitos de um incêndio espacialmente heterogêneo sobre a fenologia reprodutiva de duas espécies lenhosas dominantes, Miconia albicans (Melastomataceae) e Schefflera vinosa (Araliaceae), em uma área de cerrado no Sudeste do Brasil. A área de estudo foi parcialmente queimada por um incêndio acidental na estação seca (agosto) de 2006. Nós acompanhamos a fenologia reprodutiva de 30 indivíduos queimados e 30 não-queimados de cada espécie, de setembro de 2007 a setembro de 2008, usando aleatorizações restritas para comparar os dois grupos. Em M. albicans, a produção de estruturas reprodutivas como um todo e de botões florais, frutos e frutos maduros foi maior em indivíduos queimados do que nos não-queimados. Todos os indivíduos não-queimados, mas apenas 16% dos queimados, produziram frutos maduros durante o estudo. Já em S. vinosa, a produção de botões florais e de frutos (mas não de frutos maduros) foi maior em indivíduos queimados; aproximadamente 90% dos indivíduos de S. vinosa produziram frutos maduros durante o estudo, independentemente de terem sido queimados ou não. As diferenças entre as duas espécies podem estar relacionadas com o fato de S. vinosa crescer mais rápido e estar ausente do banco de sementes, ao contrário de M. albicans, de crescimento mais lento e dominante no banco de sementes.

Frugivory by birds on Schefflera morototoni (Araliaceae) in a Cerrado-Amazon Forest transition area, eastern Mato Grosso, Brazil / Frugivoria por aves em Schefflera morototoni (Araliaceae) em área de transição Cerrado-Floresta Amazônica, leste de Mato Grosso, Brasil

Schefflera morototoni fruits are important food source for neotropical frugivorous birds. The objectives of the present study were to record bird species that consumed fruits of S. morototoni in a forest in the transition Cerrado-Amazon Forest, Mato Grosso, Brazil and evaluate the potential of these bird species as seed dispersers of this plant species. During 31 observation hours, from November 1 to 5, 2011, 23 bird species were recorded consuming S. morototoni fruits. Out of these, 20 bird species were considered potential seed dispersers, as they swallow the fruits whole. The species consuming the greatest number of fruits were Aburria cujubi (24% of total consumed fruits), Pteroglossus castanotis (18%), Tangara palmarum (12%), Patagioenas speciosa (11%), Ramphastos toco (8%), and Dacnis lineata (5%). The species T. palmarum showed the highest visit frequency (VF = 1.51), followed by P. castanotis (VF = 0.80), and D. lineata (VF = 0.77). All bird species employed picking foraging method for removal of fruits and in 11 species (48%) this method was the only one used. Agonistic interactions represented 13% of the total number of visits. Dacnis lineata received the highest number of attacks and P. castanotis and Pitangus sulphuratus were the more aggressive species. The high bird richness and the great number of consumed fruits indicated that the fruits of S. morototoni may be an important food resource for birds in the Cerrado-Amazon Forest transition.

Os frutos de Schefflera morototoni constituem importante fonte alimentar para aves frugívoras neotropicais. Os objetivos deste estudo foram registrar as espécies de aves que consumiram frutos de S. morototoni em uma floresta na transição Cerrado- Floresta Amazônica, Mato Grosso, Brasil e avaliar a potencialidade destas espécies de aves como dispersoras de sementes desta espécie de planta. Em 31 h de observações compreendidas entre os dias 01 e 05 de novembro de 2011, registramos 23 espécies de aves consumindo os frutos de S. morototoni. Destas, 20 foram consideradas potenciais dispersoras de sementes por engolirem os diásporos inteiros. As espécies que consumiram maior número de frutos foram Aburria cujubi (24% do total de frutos consumidos), Pteroglossus castanotis (18%),Tangara palmarum (12%), Patagioenas speciosa (11%), Ramphastos toco (8%) e Dacnis lineata (5%). A espécie T. palmarum apresentou maior frequência de visita (FV= 1,51), seguida por P. castanotis (FV= 0,80) e D. lineata (FV= 0,77). Todas as espécies de aves empregaram a tática de forrageamento picking para remoção dos frutos e 11 espécies (48%) utilizaram somente essa tática. Interações agonísticas representaram 13% do número total de visitas. Dacnis lineata foi a espécie que sofreu o maior número de agressões e P. castanotis e Pitangus sulphuratus as espécies mais agressoras. A alta riqueza de aves e o elevado número de frutos consumidos mostrou que os frutos de S. morototoni são recursos alimentares importantes para a avifauna na transição Cerrado-Floresta Amazônica.

First Report and Characterization of Pestalotiopsis ellipsospora Causing Canker on Acanthopanax divaricatus

Acanthopanax divaricatus, a member of the Araliaceae family, has been used as an invigorant in traditional Korean medicine. During disease monitoring, a stem with small, irregular, brown lesions was sampled at a farm in Cheonan in 2011. The symptoms seen were sunken cankers and reddish-brown needles on the infected twig. The isolated fungal colonies were whitish, having crenated edges and aerial mycelium on the surface, and with black gregarious fruiting bodies. The reverse plate was creamy white. Conidia were 17~22 x 3.5~4.2 microm, fusiform, 4-septate, and straight to slightly curved. The nucleotide sequence of the partial translation elongation factor 1 alpha gene of the fungal isolate, shares 99% sequence identity with that of known Pestalotiopsis ellipsospora. Based on the results of the morphological and molecular analyses, the fungal isolate was identified as P. ellipsospora. In Korea, this is the first report of canker on A. divaricatus.

Chemical Constituents from Leaves of Acanthopanax henryi (II)

Nineteen compounds, including one organic acid (1), one anthraquinone (2), one amide (3), and sixteen triterpenoid saponins (4 - 19) were isolated from the leaves of Acanthopanax henryi (Oliv.) Harms (Araliaceae). Their structures were determined on the basis of physicochemical properties and spectral analyses (HR-MS and NMR). Among them, compounds 2, 3, 7, 12 and 19 were new within Araliaceae. Compounds 4, 5, 9 - 11, 13, 14, 16 and 18 were reported for the first time from the Acanthopanax genus. Except for compounds 4 and 9, other compounds were isolated from A. henryi (Oliv.) Harms for the first time. The rare anthraquinone, compound 2, significantly decreased the production of NO and the levels of other inflammatory factors, such as TNF-alpha and IL-6, in lipopolysaccharide (LPS)-stimulated macrophages in a dose-dependent manner. This is the first time to report anti-inflammatory effect of this compound.

Isolation and Identification of Terpenoids from the Fruits of Acanthopanax chiisanensis

Phytochemical constituents were isolated from the fruits of Acanthopanax chiisanensis by repeated column chromatography. Their structures were identified as beta-sitosterol (1), daucosterol (2), sesamin (3), chiisanogenin (4), and 22alpha-hydroxy chiisanogenin (5) by spectroscopic analysis (MS, 1H-, and 13C-NMR). Compounds 1 - 5 were isolated for the first time from the fruits of A. chiisanensis.

Chemical constituents from barks of Nothopanax delavayi / 中国中药杂志

Eleven compounds were isolated and purified from the barks extract of Nothopanax delavayi and their structures were identified as serratagenic acid-3-O-alpha-L-arabinopyranosyl-28-O-beta-D-glucopyranosyl ester (1), serratagenic acid-3-0-alpha-L-arabi-nopyranosyl-28-O-[alpha-L-rhamnopyranosyl-(1-->4)-beta-D-glucopyranosyl-(1-->6)-beta-D-glucopyranosyl] ester (2), serratagenic acid (3), serratagenic acid-3-O-alpha-L-arabinopyranoside (4), serratagenic acid-beta-O-beta-(2', 4'-O-diacetyl) -D-xylopyranosyl-28-O-[alpha-L-rhamnopy-ranosyl-(1-->4)-beta-D-glucopyranosyl-(1-->46)-beta-D-glucopyranosyl] ester (5), serratagenic acid-3-O-alpha-(4'-O-acetyl)-L-arabino pyrano-syl-28-0- [-alpha-L-rhamnopyranosyl-(1-->4)-beta-D-glucopyranosyl-(1-->6)-beta-D-glucopyranosyl] ester(6), serratagenic acid-3-O-alpha-(2'-O-acetyl)-L-arabinopyranosyl-28-O-[-alpha-L-rhamnopyranosyl- (1-->4) -beta-D-glucopyranosyl-(1-->6)-beta-D-glucopyranosyl] ester(7), serratagenic acid-3-0-beta-D-xylopyranosyl-28-O-[-alpha-L-rhamnopyranosyl-(1-->4)-beta-D-glucopyranosyl-(1-->6)-beta-D-glucopyranosyl] ester (8), protocatechuic acid (9), ethyl caffeate (10) and caffeic anhydride (11) by physicochemical properties and spectroscopic data analysis. Among them, compounds 3-4 and 9-11 were firstly isolated from the genus Nothopanax, and compounds 5-8 were isolated from this plant for the first time.

Advances of chemical constituents and pharmacological activities of schefflera genus / 中国中药杂志

The genus Schefflera (Araliaceae) consists of 1100 species, 35 of which can be found in China. Some species of the genus have been used in traditional medicine to treat rheumatalgia, trauma, fracture, headache, and so on. Phytochemical studies of the genus have demonstrated the presence of large number of triterpenoids and their saponins, along with some long-chain compounds, steroids and sesquiterpenes. Furthermore, many pharmacological activities of the genus such as anti-inflammatory, anticancer and antiviral activities have been reported. In this article, new development of constituents and biological activities of Schefflera genus is reviewed and summarized for its further development and utilization.

Chemical constituents contained in Macropanax rosthornii / 中国中药杂志

<p><b>OBJECTIVE</b>To study active constituents of Macropanax rosthornii in treating rheumatoid arthritis.</p><p><b>METHOD</b>Silica gel column chromatography, preparative HPLC and modern spectrum techniques were applied for a systematic study on chemical constituents contained in M. rosthornii.</p><p><b>RESULT</b>Twelve compounds were separated from M. rosthornii and identified as serratagenic acid (1), serjanic acid (2), betulinic acid (3), 6beta-hydroxy-3-oxo-olean-12-en-28-oic acid (4), 3-O-alpha-L-arabinopyranosyl serratagenic acid (5), 3-O-alpha-L-arabinopyranosyl serratagenic acid-29-methyl ester (6) , 3-O-alpha-L-arabinopyranosyl serratagenic acid-28-O-beta-D-glucopyranosyl ester (7), scopoletin (8), beta-sitosterol (9), daucosterol (10), 3,4-dihydroxybenzoic acid (11), and stearic acid (12).</p><p><b>CONCLUSION</b>Above compounds are separated from M. rosthornii for the first time.</p>

First Report of Foliar Blight on Dendropanax morbifera Caused by Alternaria panax

Leaf spot and blight disease was observed on two-year-old seedlings of Dendropanax morbifera (Korean name: Hwangchil tree) during July of 2008 in Jindo Island, Korea. Symptoms included yellow-brown to dark brown irregularly enlarged spots frequently located along the veins of leaves. The lesions were often surrounded by chlorotic haloes. Severe leaf blight and subsequent defoliation occurred when conditions favored disease outbreak. The causal organism of the disease was identified as Alternaria panax based on morphological characteristics and sequence analysis of the internal transcribed spacer region of rDNA. A. panax isolates induced leaf spots and blight symptoms not only on D. morbifera but also on the other members of Araliaceae tested. This is the first report of foliar blight caused by A. panax on D. morbifera.

Protective effect of effective part of Acanthopanacis senticosus on damage of PC12 cells induced by MPP+ / 中国中药杂志

The purpose of our research was to evaluate the protective effect of the effective part of Acanthopanacis senticosus (AS) on the damage of PC12 cells induced by MPP+, an in vitro cell model for Parkinson's disease. Cell viability and apoptosis of PC12 cells induced by MPP' were assayed by MTT and flow cytometry respectively in the presence or absence of the effective part of AS. The contents of lactate dehydrogenase (LDH), nitric oxide (NO), nitric oxide synthase (NOS) and malondialdehyde (MDA) were determined by UV spectrophotometer. Our study showed that the survival rate of PC12 cells was markedly increased while cell apoptosis was decreased in the range of 200 to 400 mg x L(-1) of the effective part of AS. The contents of LDH, NO, NOS, MDA were reduced. Our experimental results indicated that the effective part of AS had the protective effect on the damage of PC12 cells induced by MPP+. The underlying mechanisms might be the combination of reduction of LDH leakage and decreases in the contents of NO, NOS and MDA, and finally prevent the apoptosis in PC12 cells and increase the cell survival rate.

Molluscicidal saponins from leaves of Hedera canariensis

Activity-guided fractionation of the methanol extract of Hedera canariensis [var. Gloire de Maringo] Wild leaves afforded five saponins 1-5. Chemical and spectral methods [MS, [1]HNMR, [13]CNMR] showed that they are glycosides of hederagenin and oleanolic acid. The results showed that 4,5 exhibited molluscicidal properties, compound 1 was inactive. Mortality rate of exposed snails increased by increasing plant extract concentration. Lymnaea cailliaudi was more sensitive to plant extract than Biomphalaria alexandrina. The histopathological study revealed distinct damage in the structure of the stomach and ovotestis of treated L. cailliaudi snails. Saponin content was determined in term of haemolytic index

Competição entre abelhas durante forrageamento em Schefflera arboricola (Hayata) Merr / Competition among bees during foraging on Schefflera arborícola (Hayata) Merr

Schefflera arboricola (Hayata) Merr (Araliaceae) é uma planta exótica, porém amplamente cultivada no Brasil para ornamentação. Devido à abundância de flores que produz, esta árvore é altamente atrativa para abelhas Apis mellifera, bem como para diversos meliponíneos nativos. S. arboricola oferece aos seus visitantes florais pólen e néctar, que são disponibilizados ao amanhecer. A. mellifera possui ampla vantagem na coleta desses recursos devido à sua capacidade de forragear mais cedo do que os meliponíneos de pequeno e médio porte. Através de experimentos de exclusão verificou-se que as abelhas nativas mudam seu comportamento nas flores de S. arboricola em função da competição. Quando A. mellifera compete pelos mesmos recursos florais, as abelhas Scaptotrigona visitam três vezes mais flores e mudam o recurso preferencialmente coletado, pois passam a coletar pólen ao invés de néctar. Os dados obtidos sugerem que A. mellifera pode estar interferindo na dinâmica de forrageamento das abelhas Scaptotrigona.

Schefflera arboricola Hayata Merr (Araliaceae) is an exotic plant widely cultivated in Brazil for ornamental purposes. Their flowers are very attractive to Africanized honey bees (Apis mellifera) as well to several native Meliponini bees. Therefore, it is an interesting plant to test the competitive interactions and foraging overlapping among Africanized honey bees and native stingless bees. S. arboricola offers pollen and nectar to their visitors, which become available early, in the morning. A. mellifera has a large advantage in resource harvesting since can forage earlier than smaller stingless bees. By means of an exclusion experiment, it was verified that the behaviors of native bees change when they are visiting S. arboricola’s flowers in the presence of A. mellifera. When Scaptotrigona and A. mellifera are partitioning this flower resource, Scaptotrigona bees visited three times more flowers and changed the resource preference from nectar to pollen. In this context, A. mellifera may be interfering in the foraging dynamics of native Scaptotrigonabees.

Triterpenoid saponins from Polyscias paniculaia and their Schistosomicidal and Molluscicidal activities

Four triterpenoid saponins were isolated from the methanol extract of the leaves and stems of Polyscias paniculata Baker [Araliaceae]. They were identified as: 3-0[beta-D-glucuronopyranosyl oleanolic acid [1], 3-0-[beta-D-glucopyranosyl- [1-4] -beta- D-glucuronopyranosyl] oleanolic acid [2], 3 - O - beta - D-glucopyranosyl [l-4]. [beta-D-glucopyranosyl - [l-2]]- beta - D- glucuronopyranosyl oleanolic acid [3] and 3 - O - [beta D-glucopyranosyl-[l-4]-beta-D-glucuronopyranosyl] oleanolic acid -28-O-beta-D-glucopyranosyl ester [4]. Their structures were established using one- and two-dimensional NMR spectroscopy. Each pure saponin was tested for its molluscicidal and schistosomicidal activities. Saponins 2 and 3 showed a considerable schistosomicidal effect with LC[50] 14.4 and 35.7 micro g/ml, LC[90] 20.2 and 56.3 micro g/ml, respectively. Only saponin 2 showed a molluscicidal effect with a LC[50] 4.7 ppm and a LC[90] 6.6 ppm, whereas saponin the bidcsmosidic saponin 4 was inactive against the Shistosoma mansoni worms and the Biomlphalaria alexandrina snails

In vitro regeneration of Didymopanax morototoni

O presente estudo visou o estabelecimento de um completo protocolo de regeneração para Didymopanax morototoni (morototó, caixeta) uma espécie florestal nativa do Brasil. Quatro tipos de explantes (raiz, caule, nódulo foliar e folha cotiledonar) foram obtidos a partir de sementes germinadas. Na primeira etapa, meio WPM com caseína hidrolisada (250 mgL-1) e 2,4D (1,0 e 5,0 mgL-1) foram usados em combinação com cinetina (0,1 ou 1,0 mg L-1). Vinte dias depois de inoculado, o material foi avaliado. Calos embriogênicos foram divididos e transferidos para meio de expressão com várias combinações de ácido naftaleno-acético e cinetina, e repicados a cada 60 dias para meio novo. A luz não interferiu na expressão embriogênica. Embriões somáticos foram formados ou de células individuais ou de agregados de células. As plântulas foram obtidas no meio WPM com 10 g L-1 de sacarose e sem reguladores de crescimento ou com 0,1 mg L-1 de Benzil-adenina e 0,5 mg L-1 de giberelina. O desenvolvimento das plântulas a partir de embriões somáticos de D. morototoni foi alcançada em 33% dos casos.

Effects of Araliaceae Water Extracts on Blood Glucose Level and Biochemical Parameters in Diabetic Rats

This study was conducted to investigate the effects of Aralia elata, Acanthopanacis cortex and Ulmus davidiana water extracts on blood hemoglobin, HbA1c levels and biomarkers in the streptozotocin (STZ)-induced diabetic rats. Male Wistar rats divided into normal and diabetic groups. The diabetic groups subdivided into the control group (DM) and Araliaceae water extracts supplemented groups: Aralia elata (AE), Acanthopanacis cortex (AC) and Ulmus davidiana (UD). The extracts were supplemented in diet base on 11.42 g of raw Araliaceae/kg diet for 7 weeks. The diabetes was induced by injecting STZ (55 mg/kg B.W., i.p.) once 2 weeks before sacrifying. Relative weights of liver were significantly lowered in the DM group compared to the normal group, whereas those of kidney and heart were significantly increased in the DM group. Supplementation of the Araliaceae water extracts improved reduced liver weights in STZ-induced diabetic rats. Blood glucose level was significantly higher in the DM group than in the normal group, whereas insulin contents were significantly lowered in the DM groups. However, these parameters were normalized in the AE, AC and UD supplemented groups, respectively. Blood hemoglobin and HbA(1c) levels were significantly higher in the DM group than in the normal group. When all of Araliaceae water extracts were supplemented to the diabetic rats lowered hemoglobin and HbAI(1c) levels. Red blood cell, white blood cell and lymphocyte were significantly higher in the DM group than in the normal group. The supplementation of Araliaceae family water extracts significantly lowered these parameters compared to the DM group. MCV, MCH contents were declined in the DM group, while the supplementation of Aralia elata, Acanthopanacis cortex and Ulmus davidiana water extracts elevated of these contents in STZ-induced diabetic rats. Accordingly, these results indicate that Aralia elata, Acanthopanacis cortex and Ulmus davidiana water extracts would seem to improve the blood biomarkers in STZ-induced diabetic rats.